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KMID : 0379120100380020167
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Korean Journal of Mycology
2010 Volume.38 No. 2 p.167 ~ p.171
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Inhibitory Effects of Melanin Secretion on B16 Melanoma cell of Cordyceps militaris Water Extract
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Nam Byung-Hyouk
Jo Wool-Soon
Choi Yoo-Jin
Lee Jae-Yun
Kang Eung-Young
Jung Min-Ho
Lee Jae-Dong
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Abstract
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The present study aims to evaluate Cordyceps militaris water extract (CMWE) with a view to develop melanogenesis inhibitors. Inhibitory activities of CMWE against tyrosinase, L-DOPA(L-3,4-dihydroxyphenylalanine) oxidation, and melanin biosynthesis in B16 mouse melanoma cells were investigated. CMWE, at , inhibited tyrosinase activity of 71% and DOPA oxidation of 40% as reacting with L-DOPA. Furthermore, B16 mouse melanoma cell survived over 50% from low to high dose on MTT assay, and CMWE markedly inhibited (> 50%) melanin synthesis at . The inhibitory effect of CMWE on melanogenesis was attributed to enhancement of tyrosinase degradation. Key enzyme of melanin biosynthesis is tyrosinase which catalyses a beginning step from tyrosine to DOPA quinine and melanin formation step, respectively. These results indicated that CMWE may be a potential source of novel whitening agents for cosmetic or therapeutic application.
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KEYWORD
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Melanogenesis, Melanoma, Militaris, Tyrlsinase, Whitening
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